I studied in another province — does that weaken my Manitoba connection?

It doesn't disqualify you, but study or work in another province doesn't build Manitoba-specific ties on its own, and MPNP is specifically looking at your connection to Manitoba. A real job offer from a Manitoba employer, or close family living there, is what actually strengthens it. Be honest about how strong the connection genuinely is — overstating it is a common refusal reason. General information from my own experience, not legal advice — for anything specific to your file, a licensed RCIC or immigration lawyer can look at your actual documents.